Symbol
Name
ID

Socs1
suppressor of cytokine signaling 1
MGI:1354910

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Acute myeloid leukemia	Subacute progressive viral hepatitis
Disease(s) Associated with SOCS1	Acute myeloid leukemia	Subacute progressive viral hepatitis
acute myeloid leukemia
hepatocellular carcinoma

Mouse Phenotypes

heart inflammation

myocarditis

intestinal inflammation

salivary gland inflammation

thymus cortex atrophy

absent thymus corticomedullary boundary

enlarged thymus medulla

thymus hyperplasia

small thymus

thymus atrophy

decreased thymocyte number

pancreas inflammation

abnormal T cell differentiation

abnormal CD4-positive T cell differentiation

decreased eosinophil cell number

decreased B cell number

decreased pre-B cell number

abnormal T cell subpopulation ratio

decreased CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

increased NK T cell number

decreased effector memory T-helper cell number

increased regulatory T cell number

increased activated T cell number

decreased lymphocyte cell number

decreased leukocyte cell number

abnormal mature B cell morphology

abnormal follicular B cell morphology

abnormal CD4-positive, alpha beta T cell morphology

abnormal CD8-positive, alpha beta T cell morphology

abnormal spleen morphology

increased spleen red pulp amount

abnormal spleen white pulp morphology

absent spleen germinal center

abnormal lymphocyte physiology

abnormal T cell physiology

abnormal CD4-positive, alpha-beta T cell physiology

abnormal T cell activation

abnormal macrophage physiology

increased circulating interferon-gamma level

abnormal cytokine level

abnormal interleukin level

abnormal Peyer's patch morphology

abnormal lymph node B cell domain morphology

enlarged lymph nodes

lymph node hyperplasia

abnormal cytokine secretion

decreased susceptibility to experimental autoimmune encephalomyelitis

abnormal inflammatory response

increased inflammatory response

blepharitis

conjunctivitis

increased incidence of corneal inflammation

liver inflammation

myositis

glomerulonephritis

skin inflammation

dermatitis

decreased susceptibility to Togaviridae infection induced morbidity/mortality

Availability

Mouse Genotype

Socs1^tm1.1Ayr/Socs1^tm1.1Ayr

Socs1^tm1Jni/Socs1^tm1Jni

Socs1^tm1Kish/Socs1^tm1Kish

Socs1^tm1Wehi/Socs1^tm1Wehi

Socs1^tm2Wehi/Socs1^tm2Wehi

Socs1^tm3.1Wehi/Socs1^tm3.1Wehi

Socs1^tm1Jni/Socs1⁺

Socs1^tm1Ayos/Socs1^tm1Ayos
Tg(Tek-cre)1Ywa/0 (conditional)

Socs1^tm1Ayos/Socs1^tm1Ayos
Tg(Lck-cre)1Jtak/0 (conditional)

Socs1^tm1Ayos/Socs1^tm1Ayos
Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ (conditional)

Socs1^tm1Wehi/Socs1^tm3Wehi
Tg(Lck-cre)I57Jxm/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23